We describe here a rare mutation (c.700C > T; p.(Arg234Trp)) in LMNB2 in a patient suffering from a central obesity associated with hypertriglyceridemia and type 2 diabetes, acanthosis nigricans, and liver steatosis—all signs overlapping with genetic partial lipodystrophy syndrome. This evidence concerns the gene LMNB2 and type 2 diabetes mellitus.