At the molecular level and in order to investigate the pathophysiologic role of endothelial dysfunction, apoptosis, and autophagy in fibromyalgia and the potential ameliorative effect of fisetin, the mRNA gene expression of eNOS, Bcl-2, caspase-3, LC-3, BECN-1, CHOP, and TNF-α were analyzed in both the carotid artery and in cerebral cortex. The gene discussed is CASP3; the disease is endothelial dysfunction.