CDK5 and early-onset autosomal dominant Alzheimer disease: For example, in these lists, CRMP2 (collapsin response mediator protein 2; also known as dihydropyrimidinase-like protein-2, DRP2 or DPYSL2) is an abundant protein in the brain that regulates axonal growth and neuronal polarity, is phosphorylated by CDK5 at S522 and GSK3β at T509, T514, and S518, and is involved in the pathogenesis of Alzheimer’s disease [52,53,54].