C18-ceramide generation by CERS1 expression in multiple head and neck squamous cell carcinoma (HNSCC) cell lines, or their treatment with the mitochondria-accumulating ceramide analog D-e-14C18-pyridinium ceramide bromide, selectively induced lethal mitophagy independently of apoptosis [247,248]. This evidence concerns the gene CERS1 and head and neck squamous cell carcinoma.