The tumor-suppressive role of ceramide-induced mitophagy is also evident from the study in acute myeloid leukemia (AML), where FLT3-ITD (mutant Fms-like tyrosine kinase 3–internal tandem duplication) signaling downregulated the CerS1/C18-ceramide which confers its resistance to cell death [249]. The gene discussed is CERS1; the disease is acute myeloid leukemia.