However, further studies on p62/SQSTM1 are very important with respect to human health since deficiency or loss of p62/SQSTM1 could lead to amyotrophic lateral sclerosis [127,128,129], frontotemporal dementia [130] and childhood- or adolescence-onset neurodegenerative disorders [131,132]. The gene discussed is SQSTM1; the disease is amyotrophic lateral sclerosis.