However, there has been limited, at times contradictory, studies on the interplay between ApoE alleles and the levels of these ten proteins (one ACE1, nine APOs; namely, ApoAI, ApoAII, ApoAIV, ApoB, ApoCI, ApoCIII, ApoD, ApoE, and ApoH) with AD, CVD, and EMD. The gene discussed is APOA4; the disease is Alzheimer disease.