CD70 and hereditary clear cell renal cell carcinoma: CD70 expression is normally restricted to a small subset of highly activated T-cells, B cells, and dendritic cells (DCs) [166,167,168]; however, CD70 has been found to be upregulated in large B-cell leukemia and lymphoma [169], T-cell leukemia [170], renal cell carcinoma [171], and glioblastoma [172].