SCD163 levels were significantly lower in COPDS compared to COPDE (p = 0.006; Figure 1), and sCD163 levels were negatively associated with smoking pack-year history in COPD patients only (rho = −0.5, p = 0.047; Figure 1) and when HS were added (rho = −0.6, p = 0.004; Figure S1). This evidence concerns the gene CD163 and chronic obstructive pulmonary disease.