Avendaño-Ortiz J et al. showed that monocytes from patients with cystic fibrosis (CF) colonized by Pseudomonas aeruginosa exhibit a lower expression of HLA-DR+ (ratio between mean intensity of fluorescence (MIF) on LPS stimulated cells divided by MIF on unstimulated cells) than non-colonized patients [15]. This evidence concerns the gene MIF and cystic fibrosis.