ANXA5 and cancer: Since apoptosis is a vital anticancer target, used to eliminate cancer cells and maintain tissue homeostasis, we carried out annexin V/PI double staining of pine extract and abietic acid on treated-MCF-7 cells and found that abietic acid triggered cell cycle arrest in MCF-7 cells in G2/M phase as well as the SubG0-G1 subpopulation.