However, after applying a selective inhibitor of NLRP3 (MCC950), the antinociceptive effect and related protein expression of paeoniflorin and MCC950 on neuropathic pain were very similar; this suggested that the antinociceptive effect of paeoniflorin on neuropathic pain occurred by inhibiting the activity of the NLRP3 inflammasome [75]. Here, NLRP3 is linked to neuropathic pain.