NFE2L2 and major depressive disorder: Albiflorin can relieve anxiety and depression-like behavior under neuropathic pain conditions, and these effects are regulated by the Kelch-like ECH associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway; these processes reduced antioxidant levels to suppress the hippocampal activation of NLRP3 inflammation [81] (Figure 1).