Furthermore, molecular biological techniques showed that morroniside promotes the release of IL-10 mRNA and β-Endorphin precursor proopiomelanocortin (POMC) mRNA in vivo and in vitro, thus verifying that morroniside produces therapeutic effects in neuropathy via the spinal microglial expression of IL-10 and the subsequent secretion of β-Endorphin after the activation of GLP-1R [77]. This evidence concerns the gene POMC and neuropathy.