In another hand, glycosides have the characteristics of multiple targets and multiple mechanisms, including the paeoniflorin regulating p38 MAPK/NF-κB signaling pathway and anti-insulin resistance via LKB1/AMPK and AKT pathways [58,59]; salidroside has an antinociceptive effect via regulating the activation of P2X7 receptors and has neuroprotective effects on the PI3K/Akt/TERT signaling pathway [60,61]. This evidence concerns the gene AKT1 and Insulin resistance.