The primary neuropathological hallmarks of AD are proteinaceous aggregates, such as intracellular neurofibrillary tangles containing hyperphosphorylated tau and extracellular senile plaques containing amyloid-beta deposits of varying lengths [14,15,16,17], resulting in neuronal cell death and degeneration associated with memory loss and severe cognitive impairment, disrupting activities of daily living [18,19,20,21]. The gene discussed is MAPT; the disease is Alzheimer disease.