Hybrid 37a showed the highest antiproliferative activity against all cancer cells (IC50 = 10, 15 and 20 μM for SKOV3, OVCAR-3 and Caov-3, respectively) and was found to induce apoptosis on SKOV3 cells through ROS-mediated alterations in mitochondrial membrane potential (MMP), and modulated the expression of Bcl-2 and Bax proteins [78]. Here, BAX is linked to cancer.