Considering the potential of tacrine, which was used for the treatment of AD, and aiming to develop new compounds using this moiety in combination with chalcones, also known for their neuroprotective potential, Rani et al. (2021) reported the synthesis of a series of 1,2,3-triazole-linked chalcone- and ferrocenylchalcone-tacrine conjugates and their anti-AChE activity [112]. Here, ACHE is linked to Alzheimer disease.