THBS1 and neoplasm: Although sequence analysis showed the third TSP1 domain of the ADAMTS13-like from sea cucumbers shares low identities with the disintegrins from the other species, it contains an RGD motif, which indicates that the third TSP1 domain of ADAMTS13-like might possess anti-tumor activity like that of disintegrins from other species [14,15,16,24,25].