Additionally, the circulating miRNAs miR-143, miR-144, miR-199, and miR-203 were detected to be downregulated in multiple myeloma patients, and since these miRNAs might regulate the expression of Versican (a proteoglycan that promotes antigen-presenting cell tolerance in myeloma tumors), they have been proposed as biomarkers for this disease. This evidence concerns the gene VCAN and plasma cell myeloma.