Luo et al. [57] analyzed the serum samples of osteoporosis patients and human MSCs, and they concluded that miR-579-3p plays a crucial role in osteoporosis by promoting its progression, since the NAD-dependent protein deacetylase sirtuin-1 (SIRT1, which is related to osteoblasts differentiation) is directly regulated by miR-579-3p. The gene discussed is SIRT1; the disease is osteoporosis.