E2F2 and osteosarcoma: Additionally, Hua et al. [77] noticed that the survival rate of osteosarcoma patients with an elevated expression of blood let-7a (negatively regulates the E2F2, a transcription factor involved in diverse cancer pathways) was higher than that of patients with inferior expression of let-7a, and hence this miRNA could be a potent biomarker for osteosarcoma.