MCT1, herein of particular interest, works as a proton-liked bidirectional lactate shuttle and was found to be upregulated in a variety of cancer types, including breast, head, and neck, bladder, colon, or glioblastoma, and to have an important role in regulating lactate exchange between cancer cells, control lactate signaling function and promoting metastasis [20]. The gene discussed is SLC16A1; the disease is cancer.