Due to LPS, curcumin decreased inflammatory chemokines such as Interleukin 1beta (IL-1β), Interleukin 6 (IL-6) and TNF-a in mice with ALI.Furthermore, curcumin inhibited apoptotic signaling cascades such as mitogen-activated protein kinases/c-Jun NH2-terminal kinase (P38/JNK) and phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT). This evidence concerns the gene AKT1 and acute respiratory distress syndrome.