Using bisulfite genomic sequencing (BGS) showed that curcumin reversed the methylation status of the first 5 CpGs in the promoter region of the Nrf2 gene and could also remarkably suppress the anti-mecyt antibody binding to the first 5 CpGs of the Nrf2 promoter.Taken together, at least some part of curcumin potentially could have a preventive effect in prostate cancer via suppression of the Nrf2-mediated antioxidative stress cellular defense pathway [36,37]. The gene discussed is NFE2L2; the disease is prostate cancer.