TP53 and neuroblastoma: Overexpression of miR-380-5p, in combination with activated HRAS (Harvey Rat Sarcoma virus) oncoprotein, has been shown to transform primary cells, block oncogene-induced senescence and form tumours in mice, whereas inhibition of endogenous miR380-5p in neuroblastoma cells resulted in p53 induction and extensive apoptotic cell death [38].