Transgelin concentrations were higher in men (median 96.2 versus 78.8 ng/mL; Figure 1A), in patients with smoldering MM (median 149.2 versus 82.4 ng/mL; p = 0.003; Figure 1B) and in treatment-naïve patients (median 145.2 versus 82.5 ng/mL; p = 0.014; Figure 1C); however, the majority of patients with smoldering MM (5 out of 7) and treatment-naïve patients (6 out of 8) were men. The gene discussed is TAGLN; the disease is Miyoshi myopathy.