Natural products are abundant in quantity and diverse in structure, so they may target various biological processes; for example, curcumin and resveratrol are modulators of NF-κB [31,32], while Akone et al. reviewed the advances in natural products that could modulate DNA methylation and histone deacetylation [33], indicating that natural products are important sources for the discovery of drugs for the treatment of multi-factorial diseases such as RA. Here, NFKB1 is linked to rheumatoid arthritis.