IL1B and major depressive disorder: Vorinostat (SAHA), which inhibits the activity of histone deacetylases HDAC 1–3 and HDAC6, modulates inflammation and oxidative stress by reducing the level of malondialdehyde (MDA) and IL-1ß and the expression of the mRNA of the genes Nfkb1 and Hdac2 in the CORT model of depression [28].