In humans, recent studies suggest that resistin directly causes endothelial dysfunction [40] by increasing endotelin-1 (ET-1) secretion as well as vascular cell adhesion protein 1 (VCAM1) and monocyte chemoattractant protein-1 (MCP-1) and by reducing the nitric oxide synthetase [35,50]. This evidence concerns the gene RETN and endothelial dysfunction.