Obesity, insulin resistance (IR), and diabetic nephropathy exhibit faulty nuclear translocation of sXBP1 [32,33,34], where the link within sXBP1 and PI3K regulatory subunits (p85α and p85β) was disrupted, exacerbating disease etiology [34,35]. This evidence concerns the gene PIK3R2 and obesity due to melanocortin 4 receptor deficiency.