MLB’s improvement of the HFD mice’s insulin resistance strongly suggested that the restoration of the PI3K-Akt pathway not only played a role in glucose metabolism but also had an inhibitory effect on the FoxO1/MAFbx and MuRF-1 pathways and reduced obesity-associated muscle atrophy. The gene discussed is FOXO1; the disease is obesity due to melanocortin 4 receptor deficiency.