Nevertheless, reduction of fructose should be recommended for patients with NAFLD along with emerging therapies that can lower the activity of liver enzymes, fibrosis, and inflammation, such as PPARγ inhibitors (pioglitazone), SGLT-2i, and GLP-1 RA, as well as modification in gut microbiota. The gene discussed is GCG; the disease is metabolic dysfunction-associated steatotic liver disease.