Furthermore, TQ inhibited STAT3 activation and the production of STAT3-regulated gene products such as cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1, and vascular endothelial growth factor in human multiple myeloma cell lines (U266 and RPMI 8226) [185]. This evidence concerns the gene STAT3 and plasma cell myeloma.