IDO2 and neoplasm: The cellular components and secretary molecules of TME targeted by TQ as discussed here are tumor-associated macrophage(TAM), cancer-associated fibroblast(CAF), cancer-associated adipocytes(CAA), cholesterol synthesis, reactive oxygen species (ROS), eukaryotic elongation factor-2 kinase (eEF-2K), tumor-infiltrating lymphocytes (TILs), indoleamine 2,3-dioxygenase (IDO), vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), insulin-like growth factors (IGF-I), endoglin, IL-6, and JAK/STAT signaling.