TNFSF11 and Osteopenia: A recent narrative review [46] showed that isoflavones may play a significant role in preventing BMD loss: isoflavones (in particular daidzein) have showed direct effect in promoting osteoblast differentiation [285] and in suppressing the cellular expression of RANK-L [286] in in-vitro studies; also, a variety of human clinical trials assessed the potential benefit of the intake of flavonoids in osteopenia/osteoporosis and found possible positive correlation between flavonoid supplementation and attenuation of BMD loss [287,288,289].