SHBG and polycystic ovary syndrome: This ambivalence is reflected in the most recent analysis (as of 2021) including 10 randomized controlled trials with 610 patients, which showed that the supplementation of n-3 PUFAs in PCOS women can significantly improve, among others, the levels of C-reactive protein (CRP), tT, luteinizing hormone and SHBG, but did not affect the concentrations of DHEAS, free androgen index or follicle-stimulating hormone [49].