Lastly, a meta-analysis assessing the effect of n-3 PUFAs on adult females with PCOS provided—after an evaluation of eight clinical trials with a total of 298 participants—evidence that n-3 PUFA supplementation does not seem to affect the androgenic profile of adult females with PCOS, although some studies reported marginal reductions in tT or DHEAS levels [52]. The gene discussed is SULT2A1; the disease is polycystic ovary syndrome.