This hypothesis is consistent with observations in women that a high-fat diet rich in SFA increases IR and metabolic disorders amongst patients suffering from overweight and PCOS [45,46], but contrasting to, e.g., reports of a decrease in T levels after a high-fat, Western meal compared to a low-fat, high-fiber meal, and increased glucose and insulin levels after a low-fat, high-fiber meal in women with PCOS [47]. This evidence concerns the gene INS and metabolic disease.