Elevated ItI It has been reported that lipocalin-2 is upregulated in a mouse’s hippocampus under psychological stress and modulates stress-induced neuronal excitability and anxious behavior [86], which has also been considered as a potential biomarker in Alzheimer’s disease and other aging-related cognitive decline [87]. This evidence concerns the gene LCN2 and early-onset autosomal dominant Alzheimer disease.