Considering that obesity is also a risk factor for the development of T2D, a large number of proteins synthesized during the inflammatory state as CRP, adipocyte-derived metabolites such as lipids, fatty acids, adipocytokines, and various inflammatory cytokines (TNF-α, IL-1β, and IL-6), have been linked to the development of insulin resistance [13,14,15]. This evidence concerns the gene TNF and Insulin resistance.