In a murine model of asthma, exposure to NP (5 and 500 μg/kg bw∙day) in both bone-marrow derived dendritic cells (BM-DCs) and splenic classic dendritic cells CD11c(+) cDCs secreted increased levels of IL-6 and TNF-α, at both baseline and following lipopolysaccharide (LPS) stimulation [124]. The gene discussed is TNF; the disease is asthma.