After adjusting for significant factors, including coronary artery disease, age, SBP, and eGFR, the forward multivariate stepwise linear regression analysis showed that coronary artery disease (β = 0.208, adjusted R2 change = 0.035, p = 0.019) and eGFR (β = −0.247, adjusted R2 change = 0.057, p = 0.006) were significantly correlated with OPN levels in patients with hypertension. The gene discussed is SPP1; the disease is Hypertension.