According to the literature, adiponectin promotes insulin and prevents insulin resistance by suppressing gluconeogenesis and inhibiting the expression of gluconeogenic enzymes (phosphoenol pyruvate carboxy-kinase and glucose 6-phosphatase); in addition, it suppresses the absorption of fatty acids and lipogenesis, while it increases the secretion of IL-10 by macrophages, promoting the polarization of macrophages towards the M2 phenotype, which is considered to be anti-inflammatory [17,18,48,58,59]. Here, INS is linked to Insulin resistance.