To test this, we evaluated the expression and regulation of SULT1C2 in LUAD and non-tumor lung samples from different population groups, in LUAD cell lines, and under CSC exposure conditions, to determine if epigenetic regulation of SULT1C2 could be contributing to the previously observed racial disparities in lung adenocarcinoma incidence. This evidence concerns the gene SULT1C2 and lung adenocarcinoma.