In this current study, we found that a set of DEPs related to autophagy and inflammation including three upregulated DEPs (ITGA1, KNG1 and CFI) and three downregulated DEPs (FGF1, AKT2, and ATG5) were involved in the PI3K/AKT pathway, ECM-receptor interaction, and focal adhesion pathway signaling pathways and may be important biomarkers of NIHL. Here, AKT2 is linked to noise induced hearing loss.