COMT and Dyskinesia: In the 24-week, double-blind, placebo-controlled SETTLE study which enrolled patients who were treated with optimized doses of levodopa and dopamine agonists, COMT inhibitor, anticholinergics, and/or amantadine, safinamide (50 mg or 100 mg) increased the on time without dyskinesia that was troublesome as compared to placebo [11,88].