The results of the enrichment analyses, shown in Figure 4D, revealed that DEGs were primarily annotated in alcoholism, graft-versus-host disease, herpes simplex infection, TNF signaling pathway, cytokine and cytokine receptor, viral protein interaction with cytokine and cytokine receptor, Th1 and Th2 cell differentiation, toxoplasmosis, and type 1 diabetes (FDR < 0.05). The gene discussed is TNF; the disease is alcohol drinking.