The present study found that several M. koenigii miRNAs, including mko-miR8175, mko-miR5368, and mko-miR156, targeted genes encoding proteins involved in colorectal, prostate, and breast cancers, corroborating the report of Xie et al. [63], who showed that val-miR1086 and val-miR1127 from Viscum album (mistletoe) could regulate the expression level of the p53 tumor suppressor gene. Here, TP53 is linked to breast cancer.