It has a progressive and destructive course, leading to a series of complications such as stenoses, abscesses, fistulas, extraintestinal manifestation, colitis-associated neoplasia, and cancer: it is a chronic status, and its management requires several drugs such as corticosteroids, immunosuppressants, and anti-tumor necrosis factor-alpha(TNF-α) antibodies. The gene discussed is TNF; the disease is neoplasm.