Our recent studies revealed that the overexpression of microRNA-29a (miR-29a) caused NAFLD and NASH improvement [18,19,20,21,22] and that miR-29a was associated with upregulated HSP60 [23], implying that HSP60 may play a role in treating NAFLD and repression hepatic inflammation. The gene discussed is HSPD1; the disease is metabolic dysfunction-associated steatohepatitis.