Moreover, a high-dose (25 mg/kg) of the anti-rheumatoid arthritis drug auranofin (AUR) upregulates hepcidin expression and induces ferroptosis, and causes lipid peroxidation through inhibition of thioredoxin reductase (TXNRD) activity, in C57BL/6J mice and a mouse model of hemochromatosis (Hfe−/− mice) [69]. This evidence concerns the gene HFE and hemochromatosis type 1.