Given that GIP and GLP-1 are involved in glucose homeostasis, further research on the relationship between hypothalamic AMPK (considered as a regulator of the whole-body energy balance) and GIP/GLP-1 signaling could give insight into possible new therapeutic approaches for the treatment of obesity, diabetes, or neurodegenerative disorders. This evidence concerns the gene GLP1R and obesity due to melanocortin 4 receptor deficiency.