In contrast with this, GABRB1 (Gamma-aminobutyric acid type a receptor beta-1 subunit) (cg15393297), NOS1AP (Nitric oxide synthase 1 adaptor protein) (cg26663636), and TNFAIP2 (TNF-alpha-induced protein 2) (cg18620571) genes were reported to be hypermethylated in gene bodies of smokers as well as COPD when compared with a healthy group [47]. This evidence concerns the gene TNFAIP2 and chronic obstructive pulmonary disease.