SLC25A12 and epilepsy: In this section, we will address the possible mechanisms of the pathophysiology of AGC1 deficiency, focusing on refractory epilepsy and postnatal hypomyelination observed in both AGC1-deficient humans and mice as well as the failure to synthesize Gln in astrocytes [7], and DA mishandling in the nigrostriatal pathway [20] seen in aralar-KO mice.