Therefore, alterations in the LINC complex (such as the decrease in intracellular levels of nesprins and the increase in SUN1) may be responsible for the altered localization of nuclei in the cells and the increase in the nuclear area in fibroblasts derived from patients with DM1 [45], which is in accordance with our results regarding nesprins and SUN1protein levels. Here, SUN1 is linked to myotonic dystrophy type 1.