Knockout of FBXO9 in the murine hematopoietic system using the CRISPR/Cas9 system showed no effect on stem and early progenitor cells, but resulted in noticeably accelerated and aggressive development of leukemia in the mouse AML model with inversion 16 (p13q22) [70]. Here, FBXO9 is linked to acute myeloid leukemia.