In spite of their structural significant similarity, TRIB1 and TRIB2 induce AML in mice receiving bone marrow (BM) transplantations [130], downregulate C/EBPα in a proteasomal dependent manner [130], promote self-renewal in hematopoietic progenitors [130], and transduce 32D cells efficiently to block the C/EBPα-dependent 32D cell differentiation; these effects are not exerted by TRIB3 [130]. Here, TRIB2 is linked to acute myeloid leukemia.