Compared to untreated AML cells, delivery of miR-155 using transferrin-conjugated nanoparticles (Tf-NP) into AML cells increases the SH-2 containing inositol 5′ polyphosphatase 1 (SHIP1) protein (a direct miR-155 target) and cleaved caspase-3, and reduces the number of colonies [171]. Here, CASP3 is linked to acute myeloid leukemia.