In a GSEA analysis of the RNA-seq data, AML patients with high FBXW4 expression showed significantly enriched gene expression of enhancer of zeste homolog 2 (EZH2), histone deacetylase 7 (HDAC7), and lysine demethylase 1A (KDM1A), which are all key epigenetic regulators with cellular functions in tumorigenesis [64]. The gene discussed is EZH2; the disease is acute myeloid leukemia.