In addition to ubiquitination, SUMO, and NEDD8, there are other lesser investigated Ubls in AML, such as human leukocyte antigen (HLA)-F adjacent transcript 10 (FAT10), autophagy related 12 (ATG12), and ubiquitin-fold modifier 1 (UFM1). The gene discussed is UBD; the disease is acute myeloid leukemia.