TRIB3 and acute myeloid leukemia: Although there are no known specific Ub E3 ligases that promote the ubiquitin-mediated degradation of peroxisome proliferator-activated receptor-α (PPARα), TRIB3 induces ubiquitin-proteasomal degradation of PPARα to reduce the protein stability, thereby inhibiting the apoptotic function of PPARα in AML [134].