Analysis of GC from small follicles (4–8 mm diameter) of PCOS and non-PCOS patients reveal a decreased expression of the apoptotic effector caspase-3 together with an increased expression of the anti-apoptotic survival factor cIAP-2 (cellular inhibitor of apoptosis protein 2) in PCOS [120]. Here, BIRC3 is linked to polycystic ovary syndrome.