ESR1 and granular cell tumor: On the other hand, ERβ is reported to be preferentially expressed in GCT [31,136,137] along with a high expression of AR (59% of positive cells are AR positive [138]) and PR (98–100% of positive cells are PR positive), while ERα is present at moderate to high levels (20–66% of GCT are ERα positive) in these tumors [31,136,139,140,141,142].