The second was the CU-HCC score that included age (<50 or >50), albumin (≤35 or >35 g/L), bilirubin (> 18 or ≤18 umol/L), HBV DNA (≤4, 4–6 or >6 log), and cirrhosis (yes or no) to stratify patients into three groups (total score < 5, between 5 and 19, and >19) with progressively increasing risk of HCC (none in the first group, 26.8% in the second group, and 31.4% in the third group). The gene discussed is ALB; the disease is hepatocellular carcinoma.