On multivariate analysis, older age (HR: 1.06, 95% CI: 1.04–1.08), male gender (HR: 1.88, 95% CI: 1.20–2.96), HBeAg positivity (HR: 1.89, 95% CI: 1.23–2.92), baseline level of AFP level ≥ 7 ng/mL (HR: 1.93, 95% CI: 1.30–2.88), and lack of 1-year virological response (HR: 0.62, 95% CI: 0.40–0.98) were independent predictors of HCC [96]. The gene discussed is AFP; the disease is hepatocellular carcinoma.