IL6 and Glucose intolerance: While IL-6 derived from adipose tissue stimulates inflammation, glucose intolerance, and bone resorption, IL-6 derived from myocytes has an anti-inflammatory action, as it stimulates the release of IL-10 creating an anti-inflammatory environment, increasing glucose uptake, WAT lipolysis, darkening of adipocytes and improvement of metabolism [57,64,75,89].