EXOSC4 and familial pancreatic carcinoma: Cell proliferation assays revealed that knockdown of EXOSC4 by siRNA caused a marked reduction in the growth of the pancreatic cancer cell lines MIA Paca-2, AsPC-1, Hs766T, and SW1990 as well as the colorectal cancer cell line HCT116 cells (Figure 3A and Figure S4A–D).