In contrast, infection with the virulent HSV-1 strain in human corneal epithelial cells induced the NLRP3, NLRP12, and IFI16 to stimulate early inflammasome, followed by activation of caspase-1, IL-1β, and IL-18 that ultimately facilitates the recruitment of macrophage and neutrophils [180]. Here, IFI16 is linked to infection.