RNF26 and viral infectious disease: In addition, Qin et al. reported that activation of RNF26-mediated type I IFN regulation is temporal by two independent mechanisms; RNF26 interacts with STING to stabilize it during the early phase of viral infection, while RNF26 later binds to IRF3 for downregulation of IFN-mediated signaling by autophagy-associated degradation.